Chandramohan Daniel, Webster Jayne, Smith Lucy, Awine Timothy, Owusu-Agyei Seth, Carneiro Ilona
London School of Hygiene and Tropical Medicine, London, UK.
Trop Med Int Health. 2007 Jun;12(6):743-50. doi: 10.1111/j.1365-3156.2007.01844.x.
To investigate the coverage and equity of the Expanded Programme on Immunisation (EPI) and its effect on age schedule, seasonality of malaria risk, and linked intermittent preventive treatment (IPT) in West Africa.
Secondary analyses of data from a trial of IPT in Ghana. The potential effectiveness and impact of EPI-linked IPT in West Africa was calculated using the coverage of Diptheria Pertussis Tetanus vaccination obtained from national surveys and the reported protective efficacies of IPT.
In West Africa, where the transmission of malaria is highly seasonal, only 10% of malaria episodes in infants would be averted with the current coverage of EPI.
In this setting, the EPI-linked IPT is not necessarily the most appropriate approach and alternative IPT schedules and delivery systems are needed.
调查扩大免疫规划（EPI）在西非的覆盖范围和公平性，及其对年龄规划、疟疾风险季节性和联合间歇性预防治疗（IPT）的影响。
对加纳IPT试验的数据进行二次分析。利用从国家调查中获得的白喉百日咳破伤风疫苗接种覆盖率以及报告的IPT保护效力，计算EPI相关IPT在西非的潜在有效性和影响。
在疟疾传播具有高度季节性的西非，按照目前EPI的覆盖率，仅能避免10%的婴儿疟疾发作。
在这种情况下，EPI相关IPT不一定是最合适的方法，需要替代的IPT方案和实施系统。
