Zou Tao, Li Song-Lin, Hu Zhao-Yu, Cheng Si-Xue, Zhuo Ren-Xi
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
J Biomater Sci Polym Ed. 2007;18(5):519-30. doi: 10.1163/156856207780852497.
Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), (1)H nuclear magnetic resonance spectroscopy ((1)H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied.
以胆酸部分为核的星型低聚/聚（碳酸三亚甲基酯）通过胆酸与羟基引发的碳酸三亚甲基酯（TMC）的开环聚合反应合成。通过调节引发剂胆酸与单体TMC的进料比来控制星型低聚物/聚合物的分子量。通过傅里叶变换红外光谱（FT-IR）、¹H核磁共振光谱（¹H-NMR）以及尺寸排阻色谱与多角度激光光散射联用（SEC-MALLS）分析对星型低聚/聚（碳酸三亚甲基酯）进行了表征。测量了星型低聚/聚（碳酸三亚甲基酯）的水接触角。使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四氮唑（MTT）法，证明星型低聚/聚（碳酸三亚甲基酯）具有低细胞毒性。制备了基于星型聚合物的微球药物递送系统，并研究了其体外药物释放性能。
