Bonewald Lynda F
Department of Oral Biology, University of Missouri at Kansas City School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA.
Cell Metab. 2007 Jun;5(6):410-1. doi: 10.1016/j.cmet.2007.05.008.
Until recently, osteocytes have escaped the limelight, embedded within their cave-like lacunae in the mineralized matrix of bone. In this issue of Cell Metabolism, Tatsumi et al. (2007) present evidence that this "third bone cell" can send either inhibitory signals to osteoclasts to maintain bone mass with normal loading or stimulatory signals to osteoclasts to initiate bone loss upon immobilization, thereby playing an indispensable role in skeletal homeostasis.
直到最近，骨细胞一直未受到关注，它们深埋在骨矿化基质中类似洞穴的骨陷窝内。在本期《细胞代谢》杂志中，辰巳等人（2007年）提供的证据表明，这种“第三种骨细胞”既可以向破骨细胞发送抑制信号，以便在正常负荷下维持骨量，也可以向破骨细胞发送刺激信号，在固定不动时引发骨质流失，从而在骨骼内环境稳定中发挥不可或缺的作用。
