人工金属酶的定向进化：定制的蛋白质催化剂
Designed evolution of artificial metalloenzymes: protein catalysts made to order.
作者信息
Creus Marc, Ward Thomas R
机构信息
Department of Cellular and Molecular Biology, University of Neuchâtel, Rue Emile-Argand 11, C.P. 158, Neuchâtel, CH-2009, Switzerland.
出版信息
Org Biomol Chem. 2007 Jun 21;5(12):1835-44. doi: 10.1039/b702068f. Epub 2007 Apr 27.
DOI:10.1039/b702068f
PMID:17551630
Abstract
Artificial metalloenzymes based on biotin-streptavidin technology, a "fusion" of chemistry and biology, illustrate how asymmetric catalysts can be improved and evolved using chemogenetic approaches.
摘要
基于生物素-链霉亲和素技术的人工金属酶，即化学与生物学的“融合”，展示了如何利用化学遗传学方法改进和发展不对称催化剂。
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