Wan Yi-Gang, Sun Wei, Zhang Jie, Li Ming, Ruan Jian-Guo, Wang Yang, Shmizu Fujio
Department of Traditional Chinese Medicine, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(6):461-5.
The anti-Thy1.1 glomerulonephritis (GN) model induced by anti-Thy1.1 monoclonal antibody (mAb) is a widely used animal model for human mesangial proliferative glomerulonephritis (MsPGN), which is characterized by significant proteinuria and acute or progressive mesangial injury following the complement-mediated mesangiolysis and glomerular inflammatory cell infiltration. In this review, it has been discussed that the pathogenesis of reversible anti-Thy1.1 GN or irreversible anti-Thy1.1 GN induced by mAb 1-22-3 injection, the mechanisms governing inflammatory cells infiltration and several injurious cytokines in glomeruli, and some of the processes involved in the resolution of mesangial lesion such as mesangial cell proliferation and matrix expansion. Using these models, it has been reported to examine the effects of Chinese materia medica, including multi-glycoside of Tripterygium wilfordii Hook. f. (GTW) and Sairei-to on mesangial damage and proteinuria, and then to clarify the mechanism of these herbs at molecular level by examining the effects on various injurious factors.
抗Thy1.1单克隆抗体（mAb）诱导的抗Thy1.1肾小球肾炎（GN）模型是一种广泛用于人类系膜增生性肾小球肾炎（MsPGN）的动物模型，其特征是在补体介导的系膜溶解和肾小球炎性细胞浸润后出现大量蛋白尿以及急性或进行性系膜损伤。在这篇综述中，讨论了注射mAb 1-22-3诱导的可逆性抗Thy1.1 GN或不可逆性抗Thy1.1 GN的发病机制、肾小球中炎性细胞浸润和几种损伤性细胞因子的调控机制，以及系膜病变消退过程中涉及的一些过程，如系膜细胞增殖和基质扩张。利用这些模型，已有报道研究了中药，包括雷公藤多苷（GTW）和柴胡汤对系膜损伤和蛋白尿的影响，然后通过研究对各种损伤因子的作用在分子水平阐明这些草药的作用机制。
