Leimgruber A
Service d'immunologie et d'allergie CHUV, 1011 Lausanne.
Rev Med Suisse. 2007 Apr 25;3(108):1044-6, 1048-9.
Inhaled therapies are preferred to systemic ones during pregnancy and breast feeding. A real paradox exists however between the necessity to ensure an optimal treatment for pregnant women with asthma, in order to prevent fetal hypoxia, and the precaution linked to any drug prescription during pregnancy. Thus, the use of topical corticosteroids remains the first choice for asthma as well as rhinitis. Inhaled beta2-agonists are also recommended. Systemic corticosteroids may however be prescribed without hesitation when their use is required for asthma treatment. It is also interesting to note that oral second-generation antihistamines are currently allowed during pregnancy and breast feeding. This type of antihistamines is indeed to be preferred to first-generation ones that generate more side-effects and generally are thus not to be prescribed during breast feeding.
在孕期和哺乳期，吸入疗法优于全身疗法。然而，在确保为患有哮喘的孕妇提供最佳治疗以预防胎儿缺氧的必要性与孕期任何药物处方相关的预防措施之间，确实存在一个真正的矛盾。因此，局部用皮质类固醇仍然是哮喘和鼻炎的首选治疗药物。也推荐使用吸入型β2激动剂。然而，当哮喘治疗需要使用全身皮质类固醇时，可以毫不犹豫地进行处方。同样值得注意的是，目前在孕期和哺乳期允许使用口服第二代抗组胺药。这类抗组胺药确实比第一代抗组胺药更可取，第一代抗组胺药会产生更多副作用，因此通常在哺乳期不进行处方。
