合理设计的氨基末端修饰肽的抗菌活性
Antimicrobial activity of rationally designed amino terminal modified peptides.
作者信息
Bisht Gopal Singh, Rawat Diwan S, Kumar Anil, Kumar Rita, Pasha Santosh
机构信息
Peptide Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.
出版信息
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4343-6. doi: 10.1016/j.bmcl.2007.05.015. Epub 2007 May 13.
Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 microg/mL) in mammalian erythrocytes was observed.
设计并合成了一系列短的氨基末端修饰的阳离子肽。所有合成的化合物都针对革兰氏阳性菌和革兰氏阴性菌菌株进行了测试。一些化合物表现出强效抗菌活性，并且即使在高剂量水平（1000微克/毫升）下在哺乳动物红细胞中也未观察到溶血活性。
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