Shimizu Kazuyuki, Ando Masaki, Nakayama Yukiharu
Pharmaceutical Research & Technology Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki Hokusei, Inabe Mie, 511-0406, Japan.
Pharm Res. 2007 Oct;24(10):1902-9. doi: 10.1007/s11095-007-9315-3. Epub 2007 Jun 8.
We compared the compression properties and characteristics of tablets obtained using the OSDRC system (method (OSDRC)) and conventional compression methods including multi-layer compression with a pharmaceutical powder.
We prepared tablets using four methods of compression. The force profiles, ejection force, stress relaxation, pressure transmission ratio, and internal intensity of the tablets were measured as compression properties.
Method (OSDRC) gave the highest value for the crushing strength of the tablets. Although the compression properties were similar regardless of the method of compression, the internal intensity of tablets compressed by method (OSDRC) was significantly larger than that of the tablets produced by the other methods.
In terms of crushing strength, the tablets compressed by method (OSDRC) were superior of those obtained by the conventional compression method. Therefore, it is possible to increase the crushing strength of tablets without changing the pharmaceutical formulation.
我们比较了使用OSDRC系统获得的片剂（方法（OSDRC））与包括用药物粉末进行多层压片在内的传统压片方法的压缩特性。
我们采用四种压片方法制备片剂。测量了片剂的力曲线、顶出力、应力松弛、压力传递率和内部强度作为压缩特性。
方法（OSDRC）得到的片剂抗压强度值最高。尽管无论压片方法如何，压缩特性相似，但通过方法（OSDRC）压缩的片剂的内部强度明显大于其他方法生产的片剂。
就抗压强度而言，通过方法（OSDRC）压缩的片剂优于通过传统压片方法获得的片剂。因此，在不改变药物配方的情况下提高片剂的抗压强度是可能的。
