钌（II）多吡啶配合物对DNA的水解切割
Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex.
作者信息
Deshpande Megha S, Kumbhar Anupa A, Kumbhar Avinash S
机构信息
Department of Chemistry, University of Pune, Pune- 411 007, India.
出版信息
Inorg Chem. 2007 Jul 9;46(14):5450-2. doi: 10.1021/ic070331d. Epub 2007 Jun 8.
PMID:17555312
Abstract
The complex [Ru(bpy)2(BPG)]Cl2 (1) containing hydrogen-bond donor (N-H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis-Menten conditions are detailed.
摘要
含有氢键供体（N-H原子）和受体（O原子）基团的配合物[Ru(bpy)₂(BPG)]Cl₂（1）以类似酶的方式介导质粒pBR322 DNA的水解切割。详细阐述了在准米氏和真米氏条件下DNA切割的动力学方面。
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