Lam David K, Sándor George K B, Holmes Howard I, Evans A Wayne, Clokie Cameron M L
Division of Oral and Maxillofacial Surgery and Anesthesia, Mount Sinai Hospital.
J Can Dent Assoc. 2007 Jun;73(5):417-22.
Bisphosphonate-associated osteonecrosis (BON) may result in serious oral complications, such as osteomyelitis and chronic exposure of necrotic bone. Dentists must be familiar with this disorder and pay special attention to all patients on bisphosphonate therapy due to their defective osteoclast function and reduced osseous tissue vascularity, leading to impaired wound healing. The purpose of this paper is to review the history and pathogenesis of BON, discuss its differential diagnosis, provide guidance to dentists on possible measures to prevent BON and review the management of patients with BON.
双膦酸盐相关骨坏死（BON）可能导致严重的口腔并发症，如骨髓炎和坏死骨的慢性暴露。由于双膦酸盐治疗的患者破骨细胞功能缺陷和骨组织血管减少，导致伤口愈合受损，牙医必须熟悉这种疾病，并特别关注所有接受双膦酸盐治疗的患者。本文的目的是回顾BON的病史和发病机制，讨论其鉴别诊断，为牙医提供预防BON可能措施的指导，并回顾BON患者的管理。
