一种合成大麻素在神经性疼痛模型中的预先镇痛作用。
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain.
作者信息
Guindon Josée, Desroches Julie, Dani Mélina, Beaulieu Pierre
机构信息
Department of Pharmacology, Faculty of Medicine, Université de Montréal-CHUM, 3840 rue St-Urbain, Montréal, Québec, Canada H2W 1T8.
出版信息
Eur J Pharmacol. 2007 Jul 30;568(1-3):173-6. doi: 10.1016/j.ejphar.2007.04.060. Epub 2007 May 22.
The antinociceptive effects of WIN55,212-2, a synthetic cannabinoid, were evaluated in the model of partial sciatic nerve ligation after daily subcutaneous administration of 0.1 mg/kg a week before and two weeks after surgery. Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery)-Vehicle (after surgery); (2) Vehicle-WIN55,212-2; (3) WIN55,212-2-Vehicle; (4) WIN55,212-2-WIN55,212-2; (5) AM251+vehicle; (6) AM251+WIN55,212-2; (7) AM630+vehicle; (8) AM630+WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2. The decreased in mechanical allodynia and thermal hyperalgesia by WIN55,212-2 was significantly greater when it was administered during one week before surgery. In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB(1) and CB(2) receptors.
在部分坐骨神经结扎模型中，于手术前一周及手术后两周每天皮下注射0.1 mg/kg的合成大麻素WIN55,212 - 2，评估其抗伤害感受作用。对46只大鼠进行分组，分别给予：(1) 术前给予赋形剂 - 术后给予赋形剂；(2) 术前给予赋形剂 - 术后给予WIN55,212 - 2；(3) 术前给予WIN55,212 - 2 - 术后给予赋形剂；(4) 术前给予WIN55,212 - 2 - 术后给予WIN55,212 - 2；(5) AM251 + 赋形剂；(6) AM251 + WIN55,212 - 2；(7) AM630 + 赋形剂；(8) AM630 + WIN55,212 - 2；(9) 假手术组给予赋形剂；(10) 假手术组给予WIN55,212 - 2。在手术前一周给予WIN55,212 - 2时，其对机械性异常性疼痛和热痛觉过敏的减轻作用显著更强。总之，在神经性疼痛模型中，预先使用大麻素产生了更强的抗伤害感受作用，且这种作用由大麻素CB(1)和CB(2)受体介导。
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