大麻素和胍丁胺作为顺铂诱导的周围神经病变的潜在治疗替代方案。
Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy.
作者信息
Donertas Basak, Unel Cigdem Cengelli, Erol Kevser
机构信息
Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
出版信息
J Exp Pharmacol. 2018 Jun 22;10:19-28. doi: 10.2147/JEP.S162059. eCollection 2018.
Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well-known side effect of cisplatin and has the potential to result in limiting and/or reducing the dose, decreasing the quality of life. Unfortunately, the mechanism for cisplatin-induced neuropathy has not been completely elucidated. Currently, available treatments for neuropathic pain (NP) are mostly symptomatic, insufficient and are often linked with several detrimental side effects; thus, effective treatments are needed. Cannabinoids and agmatine are endogenous modulators that are implicated in painful states. This review explains the cisplatin-induced neuropathy and antinociceptive effects of cannabinoids and agmatine in animal models of NP and their putative therapeutic potential in cisplatin-induced neuropathy.
顺铂是一种广泛用于治疗各种癌症的抗肿瘤药物。周围神经病变是顺铂众所周知的副作用，有可能导致剂量受限和/或减少，降低生活质量。不幸的是，顺铂诱导神经病变的机制尚未完全阐明。目前，针对神经性疼痛（NP）的现有治疗大多只是对症治疗，效果不佳，且常常伴有多种有害副作用；因此，需要有效的治疗方法。大麻素和胍丁胺是与疼痛状态有关的内源性调节剂。这篇综述解释了在NP动物模型中顺铂诱导的神经病变以及大麻素和胍丁胺的抗伤害感受作用，及其在顺铂诱导神经病变中的潜在治疗潜力。
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