对抵抗多瘤病毒 JC 病毒感染的神经胶质细胞进行的微阵列分析表明，病毒感染与炎性细胞因子基因表达之间存在相关性。
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.
作者信息
Manley Kate, Gee Gretchen V, Simkevich Carl P, Sedivy John M, Atwood Walter J
机构信息
Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
出版信息
Virology. 2007 Sep 30;366(2):394-404. doi: 10.1016/j.virol.2007.05.016. Epub 2007 Jun 6.
Abstract
The human polyomavirus, JCV, has a highly restricted tropism and primarily infects glial cells. The mechanisms restricting infection of cells by JCV are poorly understood. Previously we developed and described a glial cell line that was resistant to JCV infection with the aim of using these cells to identify factors that determine JCV tropism. Gene expression profiling of susceptible and resistant glial cells revealed a direct correlation between the expression of inflammatory cytokines and susceptibility to JCV infection. This correlation manifested at the level of viral gene transcription. Previous studies have suggested a link between an increase in cytokine gene expression in HIV patients and the development of PML and these data supports this hypothesis.
摘要
人类多瘤病毒JCV具有高度受限的嗜性，主要感染神经胶质细胞。JCV限制细胞感染的机制尚不清楚。此前，我们开发并描述了一种对JCV感染具有抗性的神经胶质细胞系，目的是利用这些细胞来鉴定决定JCV嗜性的因素。对易感和抗性神经胶质细胞的基因表达谱分析揭示了炎性细胞因子的表达与对JCV感染的易感性之间的直接相关性。这种相关性在病毒基因转录水平上表现出来。先前的研究表明，HIV患者细胞因子基因表达的增加与进行性多灶性白质脑病的发生之间存在联系，这些数据支持了这一假设。
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