Weill François-Xavier, Tran Hoang Huy, Roumagnac Philippe, Fabre Laëtitia, Minh Nguyen Binh, Stavnes Trine Lise, Lassen Jorgen, Bjune Gunnar, Grimont Patrick A D, Guerin Philippe J
Centre National de Référence des Salmonella, Centre Collaborateur OMS de Référence et de Recherche pour les Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, INSERM U389, Institut Pasteur, Paris, France.
Am J Trop Med Hyg. 2007 Jun;76(6):1174-81.
In the last three decades, high rates of resistance to common first-line antimicrobial agents have been reported in Salmonella enterica serotype Typhi (Typhi), the causative organism of typhoid fever (TF), in many regions of the world, especially in South East Asia. Analysis of Typhi strains isolated from outbreaks and sporadic cases of TF in Son La province, northwest Vietnam, in 2002 revealed that 94.5% (85/90) of the isolates were fully susceptible to amoxicillin, chloramphenicol, cotrimoxazole, tetracycline, and nalidixic acid. There was a clear decline in the occurrence of multi-drug resistant (MDR) Typhi isolates collected in this province in 2002 (4.4%) compared with the period 1995-1999 in the same province (30.8-100%). By using molecular (IS200 profiling, PstI-ribotyping, XbaI-pulsed-field gel electrophoresis, and haplotyping) and phage-typing methods, we showed that the Typhi isolates from Son La province in 2002 were genetically related; however, they were unrelated to the previous MDR clones established in Vietnam.
在过去三十年中，世界许多地区，尤其是东南亚地区，伤寒热（TF）的病原体——伤寒沙门氏菌肠炎血清型伤寒杆菌（Typhi）对常见一线抗菌药物的耐药率很高。对2002年从越南西北部山罗省TF暴发和散发病例中分离出的Typhi菌株进行分析发现，94.5%（85/90）的分离株对阿莫西林、氯霉素、复方新诺明、四环素和萘啶酸完全敏感。与1995 - 1999年同一省份（30.8% - 100%）相比，2002年该省收集的多重耐药（MDR）Typhi分离株的发生率明显下降。通过使用分子方法（IS200分析、PstI - 核糖分型、XbaI - 脉冲场凝胶电泳和单倍型分析）和噬菌体分型方法，我们表明2002年山罗省的Typhi分离株具有遗传相关性；然而，它们与越南先前建立的MDR克隆无关。
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