Newton J R, Grillo H C, Mathisen D J
General Thoracic Surgical Unit, Massachusetts General Hospital, Boston 02114.
Ann Thorac Surg. 1991 Dec;52(6):1272-80. doi: 10.1016/0003-4975(91)90012-f.
Twenty-seven main bronchial resections (19 left, 8 right) were performed without pulmonary resection between 1975 and 1991. The patients were 17 men and 9 women with an average age of 35 years (range, 20 to 65 years). Tumors comprised 55% of the lesions, including 9 carcinoid tumors (33%), 2 mucoepidermoid tumors, 2 fibrous histiocytomas, 1 hemangiopericytoma, and 1 large cell carcinoma. Scarring and stenosis secondary to multiple causes occurred in 10 patients (37%). Two patients had miscellaneous lesions. Presenting symptoms included dyspnea (52%), wheezing or stridor (44%), cough (41%), hemoptysis (37%), and pneumonia (18%). Preoperative chest roentgenogram was abnormal in 60% of patients, whereas tomograms delineated the lesion in 94%. All patients had bronchoscopy for lesion evaluation. Anesthesia was accomplished through a long single-lumen endotracheal tube in 19 cases and a double-lumen tube in 8 cases. Mobilization and exposure techniques to create a tension-free anastomosis were critical for left main bronchial resections and included pretracheal mobilization (100%), neck flexion (100%), tracheal and main bronchial retraction (85%), aortic and pulmonary artery retraction (44%), and intrapericardial hilar release (33%). All resections were for cure; there was no operative mortality. Morbidity in 4 patients (15%) included an anastomotic stenosis (successfully reresected), prolonged air leak and pneumonia, transient recurrent nerve palsy, and atelectasis. Median 5-year follow-up revealed 92% of patients alive, with only one of two late deaths being disease-related. Main bronchial resection is an ideal technique for selected benign and malignant lesions, allowing complete pulmonary parenchymal preservation.
1975年至1991年间,在未进行肺切除的情况下实施了27例主支气管切除术(19例左侧,8例右侧)。患者包括17名男性和9名女性,平均年龄35岁(范围为20至65岁)。肿瘤占病变的55%,其中包括9例类癌肿瘤(33%)、2例黏液表皮样肿瘤、2例纤维组织细胞瘤、1例血管外皮细胞瘤和1例大细胞癌。10例患者(37%)出现多种原因导致的瘢痕形成和狭窄。2例患者有其他病变。主要症状包括呼吸困难(52%)、喘息或喘鸣(44%)、咳嗽(41%)、咯血(37%)和肺炎(18%)。60%的患者术前胸部X线片异常,而断层扫描在94%的患者中显示出病变。所有患者均接受支气管镜检查以评估病变。19例患者通过长单腔气管插管进行麻醉,8例患者通过双腔气管插管进行麻醉。对于左主支气管切除术,建立无张力吻合的游离和暴露技术至关重要,包括气管前游离(100%)、颈部屈曲(100%)、气管和主支气管牵拉(85%)、主动脉和肺动脉牵拉(44%)以及心包内肺门松解(33%)。所有切除均为根治性;无手术死亡。4例患者(15%)出现的并发症包括吻合口狭窄(成功再次切除)、持续漏气和肺炎、短暂性喉返神经麻痹以及肺不张。中位5年随访显示92%的患者存活,2例晚期死亡中仅1例与疾病相关。主支气管切除术是治疗某些良性和恶性病变的理想技术,可完整保留肺实质。