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保留实质的支气管袖状切除术治疗低度恶性疾病

Parenchyma-Sparing Bronchial Sleeve Resection in Low-Grade Malignant Diseases.

作者信息

Salimbene Ottavia, Voltolini Luca, Mercier Olaf, Viggiano Domenico, Hanna Amir, Gonfiotti Alessandro, Fadel Elie

机构信息

Division of Thoracic Surgery, Careggi University Hospital, 50134 Florence, Italy.

Division of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Paris-Sud University, 92350 Le Plessis Robinson, France.

出版信息

Cancers (Basel). 2025 Jun 26;17(13):2156. doi: 10.3390/cancers17132156.

Abstract

: Sleeve and wedge bronchial resections without removal of lung tissue may represent a surgical option in selected cases of low-grade neoplasms. This study is a retrospective analysis of the surgical technique and the short- and long- term results of bronchial sleeve resections performed in the Department of Thoracic Surgery of Careggi Hospital in Florence, Italy, and in the Department of Thoracic Surgery of Marie Lannelongue Hospital in Plessis Robinson, France. : Between January 2017 and October 2024, 25 patients with low-grade tumors underwent bronchial sleeve resection with total lung-sparing. We collected the preoperative data, surgical techniques, postoperative results and long-term oncologic outcomes. : We performed 25 bronchial sleeves which resulted in 20 typical carcinoids (TC), 3 atypical carcinoids (AT) and 2 mucoepidermoid carcinomas. Three patients had R1 resection, and one of them also had N1 disease; a multidisciplinary team opted for a "watch and wait" policy without adjuvant therapies. No local recurrences occurred, although three distant recurrences were observed. The five-year overall survival (OR) rate was 100%; the five-year disease-free survival (DFS) rate was 80%. : Bronchoplastic procedures without lung parenchyma resection are an appropriate and feasible technique for selected cases of low-grade endobronchial neoplasms.

摘要

在某些低级别肿瘤病例中,不切除肺组织的袖状和楔形支气管切除术可能是一种手术选择。本研究是对意大利佛罗伦萨卡雷吉医院胸外科和法国普莱西斯拉罗宾逊玛丽·拉内隆格医院胸外科所进行的支气管袖状切除术的手术技术以及短期和长期结果的回顾性分析。:在2017年1月至2024年10月期间,25例低级别肿瘤患者接受了全肺保留的支气管袖状切除术。我们收集了术前数据、手术技术、术后结果和长期肿瘤学结局。:我们进行了25例支气管袖状切除术,结果显示有20例典型类癌(TC)、3例非典型类癌(AT)和2例黏液表皮样癌。3例患者为R1切除,其中1例还伴有N1疾病;一个多学科团队选择了“观察等待”策略,未进行辅助治疗。尽管观察到3例远处复发,但未发生局部复发。五年总生存率(OR)为100%;五年无病生存率(DFS)为80%。:对于某些低级别支气管内肿瘤病例,不切除肺实质的支气管成形术是一种合适且可行的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1546/12249397/6bd864e8d540/cancers-17-02156-g001.jpg

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