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[妊娠期自发性肝出血:一种罕见且危及生命的情况]

[Spontaneous liver haemorrhage during pregnancy: a rare and life-threatening situation].

作者信息

Boormans E M A, Bekedam D J, Lenters E, Schoonderbeek F J, Tilanus H W

机构信息

Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Verloskunde en Gynaecologie, Amsterdam.

出版信息

Ned Tijdschr Geneeskd. 2007 May 26;151(21):1157-62.

Abstract

Three pregnant women, of whom 2 were 33 and 1 was 35 years of age, were seen; 2 of them had upper abdominal pain and 1had oedema. All had proteinuria and liver enzyme abnormalities, and pre-eclampsia or the HELLP syndrome was suspected. They were consequently admitted and at first treated with antihypertensive agents. One patient underwent a Caesarean section and the baby had a good start. Afterwards, however, the patient developed shock. A CT-scan revealed a hepatic rupture, for which repeated surgical packing of the liver was carried out. The postoperative course was complicated. A second patient developed shock and the foetus died. Here the CT-scan revealed a liver haematoma. At surgery the next day, removal of the foetus was followed by heavy uterine bleeding. The patient again developed shock and the uterus was resected. A haematoma that was seen in the liver was treated expectatively. The postoperative course was not complicated. In a third patient, abdominal echography revealed bleeding from the liver. Simultaneous Caesarean section and surgical exploration of the liver took place, with packing of the liver. The child had Apgar scores of 4, 7 and 9. After re-laparotomy because of persistent bleeding from the liver the patient recovered. Spontaneous liver haemorrhage and hepatic rupture during pregnancy is a rare condition associated with significant maternal and perinatal mortality. The majority of cases occur during pregnancies complicated by pre-eclampsia or the HELLP syndrome. The presenting symptoms are non-specific. A high index of suspicion is important and early evaluation with imaging is necessary to improve the prognosis of both mother and child.

摘要

共诊治了3名孕妇,其中2名33岁,1名35岁;2人有上腹部疼痛,1人有水肿。她们均有蛋白尿和肝酶异常,怀疑为子痫前期或HELLP综合征。因此她们入院并首先接受了抗高血压药物治疗。1例患者接受了剖宫产,婴儿情况良好。然而,之后该患者发生休克。CT扫描显示肝破裂,遂对肝脏进行了反复手术填塞。术后病程复杂。第2例患者发生休克,胎儿死亡。此处CT扫描显示肝脏血肿。次日手术时,取出胎儿后出现大量子宫出血。患者再次发生休克,子宫被切除。肝脏发现的血肿采取保守治疗。术后病程未出现并发症。第3例患者腹部超声检查显示肝脏出血。同时进行了剖宫产和肝脏手术探查,并对肝脏进行了填塞。婴儿阿氏评分分别为4分、7分和9分。因肝脏持续出血再次剖腹手术后,患者康复。妊娠期间自发性肝出血和肝破裂是一种罕见疾病,与母婴严重死亡率相关。大多数病例发生在合并子痫前期或HELLP综合征的妊娠期间。其表现症状不具特异性。高度怀疑很重要,早期进行影像学评估对于改善母婴预后很有必要。

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