Fry Andrew C, Karet Fiona E
Department of Medical Genetics and Division of Renal Medicine, University of Cambridge, Cambridge Institute for Medical Research, UK.
Physiology (Bethesda). 2007 Jun;22:202-11. doi: 10.1152/physiol.00044.2006.
Inherited acidosis may result from a primary renal defect in acid-base handling, emphasizing the central role of the kidney in control of body pH; as a secondary phenomenon resulting from abnormal renal electrolyte handling; or from excess production of acid elsewhere in the body. Here, we review our current understanding of the inherited renal acidoses at a genetic and molecular level.
遗传性酸中毒可能源于酸碱处理方面的原发性肾脏缺陷，这突出了肾脏在控制身体pH值方面的核心作用；也可能是由于肾脏电解质处理异常导致的继发性现象；或者是身体其他部位酸产生过多所致。在此，我们从基因和分子层面回顾一下目前对遗传性肾脏酸中毒的认识。
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