儿童中由除金黄色葡萄球菌外的葡萄球菌引起的医院获得性脑膜炎：多中心研究

Nosocomial meningitis caused by Staphylococcus other than S. aureus in children: multicentre study.

作者信息

Bauer F, Huttova M, Rudinsky B, Benca J, Taziarova M, Kovac M, Balent I, Sulla I, Jarcuska P, Kalavsky E, Kisac P, Holeckova K, Ondrusova A, Kralinsky K, Stankovic I, Steno J, Pevalova L, Grey E, Mrazova M, Spanik S

机构信息

School of Medicine and School of Health, Department of Neurology, Neurosurgery, Bratislava, Kosice, Banska Bystrica, Nitra, Slovakia.

出版信息

Neuro Endocrinol Lett. 2007 Jun;28 Suppl 2:34-5.

PMID:17558376

Abstract

Analysing 101 cases of nosocomial meningitis due to staphylococci other than S. aureus within last 15 years, coagulase negative staphylococci represented the commonest pathogen. Major risk factor for staphylococcal meningitis was prior neurosurgery, mainly ventriculoperitoneal shunt insertion. Ten of 101 cases were caused by glycopeptide intermediate resistant strains in patients pretreated with multiple combination of antibiotics including vancomycin and shunt exchanges: 76% of strains were also oxacillin resistant.

摘要

分析过去15年里101例由除金黄色葡萄球菌之外的葡萄球菌引起的医院获得性脑膜炎病例，凝固酶阴性葡萄球菌是最常见的病原体。葡萄球菌性脑膜炎的主要危险因素是既往神经外科手术，主要是脑室腹腔分流术。101例中有10例是由糖肽类中介耐药菌株引起的，这些患者接受了包括万古霉素在内的多种抗生素联合治疗及分流装置更换：76%的菌株也对苯唑西林耐药。