Tirupati Srinivasan, Chua Ling-Ern
Hunter New England Area Health Services, James Fletcher Hospital, Newcastle, NSW, Australia.
Aust N Z J Psychiatry. 2007 Jul;41(7):606-10. doi: 10.1080/00048670701392841.
People with schizophrenia and bipolar disorders suffer from increased rates of obesity and metabolic syndrome. Metabolic disorders add to the burden of disease and affect treatment and rehabilitation outcomes. This study aimed to study the prevalence of obesity and metabolic syndrome in people with chronic psychotic disorders in a psychiatric rehabilitation setting.
All patients in the psychiatry rehabilitation program were assessed for obesity and metabolic syndrome using the definition of International Diabetes Federation (2005) was conducted as part of clinical protocol recently introduced into practice.
A total of 221 patients were assessed. The prevalence of obesity was 59% and metabolic syndrome 68%. Metabolic syndrome was more frequent in patients receiving polypharmacy with multiple antipsychotics and mood stabilisers. Rates of nontreatment for metabolic disorders ranged from 30% to 88%.
The rates of obesity and metabolic syndrome in patients with chronic severe mental disorders on antipsychotic drug treatment were 2 to 3 times that in the general population. A majority of them were untreated. Detection, monitoring and appropriate treatment of obesity and metabolic disorders should be a component of an assertive care management program to reduce morbidity and mortality and improve rehabilitation outcomes.
精神分裂症和双相情感障碍患者的肥胖率和代谢综合征发病率有所上升。代谢紊乱加重了疾病负担,影响治疗和康复效果。本研究旨在探讨在精神科康复环境中慢性精神障碍患者肥胖和代谢综合征的患病率。
根据国际糖尿病联盟(2005年)的定义,对精神科康复项目中的所有患者进行肥胖和代谢综合征评估,这是最近引入临床方案的一部分。
共评估了221例患者。肥胖患病率为59%,代谢综合征患病率为68%。在接受多种抗精神病药物和情绪稳定剂联合用药的患者中,代谢综合征更为常见。代谢紊乱的未治疗率在30%至88%之间。
接受抗精神病药物治疗的慢性重度精神障碍患者的肥胖和代谢综合征发病率是普通人群的2至3倍。其中大多数未得到治疗。肥胖和代谢紊乱的检测、监测及适当治疗应成为积极护理管理项目的一部分,以降低发病率和死亡率,改善康复效果。