Zhang Honghai, Liu Rui, Huang Weida
Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, PR China.
Immunol Invest. 2007;36(3):233-46. doi: 10.1080/08820130600992073.
Heat shock protein 70 (Hsp70) has been found to play key roles in tumor immunity due its chaperone function of binding antigenic peptides. Here we report it can also stimulate NK cells in vivo, which is another role in Hsp70s' anti-tumor response. Injecting Hsp70 into mice increased splenic NK cell populations, which may be reason for anti-tumor effect of Hsp70. The Hsp70 14-mer peptide (aa450-463, TRD) was identified as the critical epitope for this stimulatory activity. It was the murine Hsp70 14-mer peptide TRD instead of the corresponding human Hsp70 14-mer peptide TKD that functioned in the mouse experimental model.
热休克蛋白70（Hsp70）因其结合抗原肽的伴侣功能而在肿瘤免疫中发挥关键作用。在此我们报告，它还能在体内刺激自然杀伤细胞（NK细胞），这是Hsp70抗肿瘤反应的另一作用。将Hsp70注射到小鼠体内可增加脾脏NK细胞数量，这可能是Hsp70具有抗肿瘤作用的原因。Hsp70的14聚体肽（氨基酸450 - 463，TRD）被确定为这种刺激活性的关键表位。在小鼠实验模型中起作用的是小鼠Hsp70的14聚体肽TRD，而非相应的人Hsp70的14聚体肽TKD。
