Uthra Satagopan, Raman Rajiv, Mukesh Bickol N, Padmaja Kumari R, Paul Pradeep G, Lakshmipathy Praveena, Gnanamoorthy Perumal, Sharma Tarun, McCarty Catherine A, Kumaramanickavel Govindasamy
SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India.
Ophthalmic Genet. 2007 Jun;28(2):77-81. doi: 10.1080/13816810701209669.
A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.
内皮型一氧化氮合酶（eNOS）基因第4内含子中的一段27个碱基对的可变数目串联重复序列（VNTR）已被证明与不同种族人群患糖尿病视网膜病变（DR）的风险相关。本研究纳入了来自印度南部的187例患有视网膜病变的患者（病例组；DR+）和188例无视网膜病变的患者（对照组：DR-），这些患者均患有2型糖尿病（T2DM）且病程超过10年。我们既未发现该VNTR与DR的临床严重程度之间存在显著的等位基因关联，也未发现其与黄斑水肿之间存在显著关联。我们的研究结果表明，在印度南部，eNOS基因第4内含子VNTR与DR之间不存在关联。
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