溴哌利多在人肝脏中转化为还原型溴哌利多。
Conversion of bromperidol to reduced bromperidol in human liver.
作者信息
Someya T, Inaba T, Tyndale R F, Tang S W, Takahashi S
机构信息
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
出版信息
Neuropsychopharmacology. 1991 Nov;5(3):177-82.
PMID:1755933
Abstract
Bromperidol (BRP) is an analog of haloperidol, a potent butyrophenone neuroleptic. Reductive conversion of BRP carbonyl group to reduced bromperidol (RBRP) was confirmed in vitro using human liver. This NADPH-dependent reduction of BRP showed a similar inhibition pattern and Michaelis constants to haloperidol carbonyl reductase.
摘要
溴哌利多（BRP）是氟哌啶醇的类似物，氟哌啶醇是一种强效的丁酰苯类抗精神病药物。在体外用人肝脏证实了BRP羰基还原为还原型溴哌利多（RBRP）的过程。BRP的这种依赖烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的还原反应，与氟哌啶醇羰基还原酶表现出相似的抑制模式和米氏常数。
Zotero 插件