Skamene E, Pietrangeli C E
McGill University, Montreal, Canada.
Curr Opin Immunol. 1991 Aug;3(4):511-7. doi: 10.1016/0952-7915(91)90013-q.
In this selective review of the recent literature in the field of genetically determined host resistance to infection, we highlight five areas in which research is directed towards the search for proteins encoded by genes that function to maintain a 'resistant' phenotype in the face of challenge by a variety of pathogenic organisms. In particular, we discuss newly described genes that may regulate host resistance, newly described functions of genes previously identified, the reverse genetics approach to cloning an elusive gene, a direct genetics approach to a similar problem, and the role of the major histocompatibility complex in regulating our ability to resist challenge by infectious organisms.
在本次对基因决定的宿主抗感染领域近期文献的选择性综述中，我们重点介绍了五个研究方向，这些研究致力于寻找由基因编码的蛋白质，这些蛋白质在面对多种致病生物体的挑战时，发挥维持“抗性”表型的作用。特别是，我们讨论了可能调节宿主抗性的新发现基因、先前已鉴定基因的新发现功能、克隆难以捉摸基因的反向遗传学方法、针对类似问题的正向遗传学方法，以及主要组织相容性复合体在调节我们抵抗感染性生物体挑战能力方面的作用。
