Noor Aliya, Knox Kenneth S
Division of Pulmonary and Critical Care Medicine, Indiana University and the Richard L. Roudebush VA Medical Center, Indianapolis, IN.
Clin Dermatol. 2007 May-Jun;25(3):250-8. doi: 10.1016/j.clindermatol.2007.03.002.
The immunopathogenesis of sarcoidosis has been difficult to charaterize given the heterogeneity of disease, the elusiveness of the causative antigen, and the lack of an adequate animal model. However, by examining well-defined clinical cohorts, the interplay between genetic predisposition and immunologic response has been increasingly informative. Technological advances in cellular analysis have allowed researchers to characterize the immune responses important in the maintenance of granulomatous inflammation. Finally, "new" clinical observations such as granuloma responsiveness to targeted biological therapies, sarcoid developing during immune restoration, and the relationship between sarcoidosis and Hepatitis C will provide future insight to the immunopathogenesis of sarcoidosis.
鉴于结节病的异质性、致病抗原难以捉摸以及缺乏合适的动物模型，其免疫发病机制一直难以明确。然而，通过研究定义明确的临床队列，遗传易感性与免疫反应之间的相互作用已越来越具有启发性。细胞分析技术的进步使研究人员能够描述在维持肉芽肿性炎症中起重要作用的免疫反应。最后，诸如肉芽肿对靶向生物疗法的反应、免疫恢复过程中出现的结节病以及结节病与丙型肝炎之间的关系等“新”临床观察结果将为结节病的免疫发病机制提供未来的见解。
