Tandon V, Das B
Department of Zoology, North Eastern Hill University, Shillong 793022, India.
Methods. 2007 Aug;42(4):330-8. doi: 10.1016/j.ymeth.2007.01.005.
The root tuber peel of Flemingia vestita has been in use in local traditional medicine against intestinal worm infections in Meghalaya (North-East India). In order to evaluate and authenticate the anthelminitc efficacy of the isoflavones of F. vestita, the root peel extract of this putative plant was tested against several helminth parasites, extensively on Rallietina echinobothrida, with respect to different parameters of these parasites. In this paper, we describe various methods to evaluate the anthelmintic efficacy of this medicinal plant with respect to carbohydrate metabolism in R. echinobothrida at paralytic time caused by the isoflavones of F. vestita. To meet the high energy demand by the parasite due to the anthelmintic stress, glucose breakdown follows the PEPCK-malate pathway in the parasite.
绒毛千斤拔的块根外皮在印度东北部梅加拉亚邦的当地传统医学中用于治疗肠道蠕虫感染。为了评估和验证绒毛千斤拔异黄酮的驱虫效果，对这种假定植物的根皮提取物针对几种蠕虫寄生虫进行了测试，特别是针对棘盘瑞利绦虫，研究了这些寄生虫的不同参数。在本文中，我们描述了各种方法来评估这种药用植物对绒毛千斤拔异黄酮导致棘盘瑞利绦虫麻痹时碳水化合物代谢的驱虫效果。为了满足寄生虫因驱虫应激而产生的高能量需求，寄生虫体内的葡萄糖分解遵循磷酸烯醇式丙酮酸羧激酶-苹果酸途径。
