Iciek Małgorzata, Marcinek Joanna, Mleczko Urszula, Włodek Lidia
Chair of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 7, PL 31-034 Kraków, Poland.
Eur J Pharmacol. 2007 Aug 13;569(1-2):1-7. doi: 10.1016/j.ejphar.2007.04.055. Epub 2007 May 22.
The present in vivo studies demonstrated that diallyl disulfide (DADS), occurring in garlic, elevated hepatic sulfane sulfur level and activities of gamma-cystathionase and 3-mercaptopyruvate sulfotransferase in healthy mice but did not affect the hepatic glutathione level. DADS efficiently corrected the concentrations of glutathione and sulfane sulfur, and ameliorated gamma-cystathionase activity that had been lowered in the livers of Ehrlich ascites tumor-bearing mice. In Ehrlich ascites tumor cells, diallyl disulfide did not alter bound sulfane sulfur level, sulfotransferases activity or glutathione level. These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy.
目前的体内研究表明，大蒜中含有的二烯丙基二硫化物（DADS）可提高健康小鼠肝脏中的硫烷硫水平以及γ-胱硫醚酶和3-巯基丙酮酸硫转移酶的活性，但不影响肝脏中的谷胱甘肽水平。DADS有效纠正了艾氏腹水癌荷瘤小鼠肝脏中降低的谷胱甘肽和硫烷硫浓度，并改善了γ-胱硫醚酶活性。在艾氏腹水癌细胞中，二烯丙基二硫化物不会改变结合硫烷硫水平、硫转移酶活性或谷胱甘肽水平。这些数据表明，该化合物仅能在肝脏中有效且选择性地发挥作用，可用于化疗期间的肝脏保护。
