Kuvshinoff Boris, Fong Yuman
Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA.
Semin Oncol. 2007 Jun;34(3):177-85. doi: 10.1053/j.seminoncol.2007.03.003.
The liver is the most common site of metastatic disease from both gastrointestinal and extra-intestinal malignancies. Historically, only a minority of patients with colorectal liver metastases were candidates for resection. However, over the past several decades, liver resection has evolved as a safe and potentially curative treatment for hepatic colorectal metastases. The development of active chemotherapy and molecular targeted therapies, together with newer modalities like radiofrequency ablation, have expanded the indications for hepatic resection and improved survival. Selected patients with isolated liver metastases from neuroendocrine tumors, germ cell cancers, ocular melanoma, gastrointestinal stromal tumors (GIST), and breast cancer also may be considered for hepatic surgery.
肝脏是胃肠道和肠外恶性肿瘤转移最常见的部位。从历史上看，只有少数结直肠癌肝转移患者适合进行手术切除。然而，在过去几十年中，肝切除术已发展成为一种治疗肝结直肠癌转移安全且可能治愈的方法。积极化疗和分子靶向治疗的发展，以及诸如射频消融等更新的治疗方式，扩大了肝切除术的适应症并提高了生存率。来自神经内分泌肿瘤、生殖细胞癌、眼黑色素瘤、胃肠道间质瘤（GIST）和乳腺癌的孤立性肝转移的特定患者也可考虑进行肝脏手术。
