Kanner Andrew A, Bokstein Felix, Blumenthal Deborah T, Ram Zvi
Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Semin Oncol. 2007 Jun;34(3):197-205. doi: 10.1053/j.seminoncol.2007.03.011.
Brain metastases are the most common intracranial tumors in adults and source of the most common neurological complications of systemic cancer. The treatment approach to brain metastases differs essentially from treatment of systemic metastases due to the unique anatomical and physiological characteristics of the brain. Surgery and radiosurgery are important components in the complex treatment of brain metastases and can prolong survival and improve the quality of life (QOL). Aggressive intervention may be indicated for selected patients with well-controlled systemic cancer and good performance status in whom central nervous system (CNS) disease poses the greatest threat to functionality and survival. In this review the respective roles of surgery and radiosurgery, patient selection, general prognostic factors and tailoring of optimal surgical management strategies for cerebral metastases are discussed.
脑转移瘤是成人最常见的颅内肿瘤，也是全身癌症最常见的神经并发症来源。由于大脑独特的解剖和生理特征，脑转移瘤的治疗方法与全身转移瘤的治疗方法有本质区别。手术和放射外科是脑转移瘤综合治疗的重要组成部分，可延长生存期并改善生活质量（QOL）。对于全身癌症得到良好控制且体能状态良好、中枢神经系统（CNS）疾病对功能和生存构成最大威胁的特定患者，可能需要积极干预。在本综述中，将讨论手术和放射外科的各自作用、患者选择、一般预后因素以及针对脑转移瘤的最佳手术管理策略的调整。
