Blazer Dan G, Sondak Vernon K, Sabel Michael S
Division of Surgical Oncology, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Semin Oncol. 2007 Jun;34(3):270-80. doi: 10.1053/j.seminoncol.2007.03.007.
For most solid tumors therapy has evolved from surgery alone to a multidisciplinary approach. Malignant melanoma remains an exception, with surgery maintaining the principal role not only for treatment of the primary lesion but also staging and the management of advanced disease. The surgical management of melanoma has evolved over the years, resulting in a substantial decrease in the morbidity associated with treatment without a compromise in outcome. This article will review the changes that have occurred leading to the current surgical approach to melanoma, the evidence behind these recommendations, and new questions that need to be addressed.
对于大多数实体瘤，治疗方法已从单纯手术发展为多学科方法。恶性黑色素瘤仍然是个例外，手术不仅在原发性病变的治疗中，而且在分期和晚期疾病的管理中都保持着主要作用。多年来，黑色素瘤的手术管理不断发展，在不影响治疗效果的情况下，与治疗相关的发病率大幅降低。本文将回顾导致目前黑色素瘤手术方法的变化、这些建议背后的证据以及需要解决的新问题。
