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将加州大学洛杉矶分校经皮冠状动脉介入治疗(PCI)与扩展前列腺癌指数综合指标相联系的分析:对日本局限性前列腺癌男性患者健康相关生活质量的评估

Analysis linking UCLA PCI with Expanded Prostate Cancer Index Composite: an evaluation of health related quality of life in Japanese men with localized prostate cancer.

作者信息

Namiki Shunichi, Takegami Misa, Kakehi Yoshiyuki, Suzukamo Yoshimi, Fukuhara Shunichi, Arai Yoichi

机构信息

Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

J Urol. 2007 Aug;178(2):473-7; discussion 477. doi: 10.1016/j.juro.2007.03.113. Epub 2007 Jun 11.

Abstract

PURPOSE

We evaluated the correspondence between UCLA PCI and the Extended Prostate Cancer Index Composite for Japanese patients with localized prostate cancer.

MATERIALS AND METHODS

A total of 385 patients treated with retropubic radical prostatectomy, external beam radiation, hormonal therapy or select watchful waiting from 2002 to 2006 were enrolled. For this study we used equipercentile linking, a technique that identifies scores on the 2 measures that have the same percentile rank.

RESULTS

Urinary and sexual functions showed a strong correlation (r = 0.85 and 0.93, respectively, p <0.0001). In contrast, the correlation for bowel function was relatively weak (r = 0.47, p <0.0001). The correlations of each Extended Prostate Cancer Index Composite bother domain with UCLA PCI were 0.6 (p <0.0001). The linking between each scale of the Extended Prostate Cancer Index Composite and UCLA PCI domains showed that an Extended Prostate Cancer Index Composite urinary function score of 73 was equivalent to a UCLA PCI score of 60. With regard to urinary bother an Extended Prostate Cancer Index Composite score of 69 to 84 was equivalent to a UCLA PCI score of 75. A sexual function score of 18 on UCLA PCI corresponded to an Extended Prostate Cancer Index Composite score of 12 and a sexual bother score of 50 on UCLA PCI corresponded to an Extended Prostate Cancer Index Composite score of 56 to 88.

CONCLUSIONS

The urinary and sexual domains of UCLA PCI and the Extended Prostate Cancer Index Composite showed strong correlations. In contrast, the correlation for the bowel domain was relatively weak. The results of the linking analysis between UCLA PCI and the Extended Prostate Cancer Index Composite may have implications useful for their interpretation.

摘要

目的

我们评估了美国加州大学洛杉矶分校前列腺癌指数(UCLA PCI)与日本局限性前列腺癌患者的扩展前列腺癌指数综合评分(Extended Prostate Cancer Index Composite)之间的相关性。

材料与方法

纳入了2002年至2006年期间接受耻骨后根治性前列腺切除术、外照射放疗、激素治疗或选择观察等待的385例患者。在本研究中,我们使用了等百分位链接法,这是一种确定两种测量方法上具有相同百分位排名分数的技术。

结果

排尿和性功能显示出很强的相关性(分别为r = 0.85和0.93,p <0.0001)。相比之下,肠道功能的相关性相对较弱(r = 0.47,p <0.0001)。扩展前列腺癌指数综合评分的每个困扰领域与UCLA PCI的相关性为0.6(p <0.0001)。扩展前列腺癌指数综合评分与UCLA PCI各领域之间的链接显示,扩展前列腺癌指数综合排尿功能评分为73相当于UCLA PCI评分为60。关于排尿困扰,扩展前列腺癌指数综合评分为69至84相当于UCLA PCI评分为75。UCLA PCI上的性功能评分为18相当于扩展前列腺癌指数综合评分为12,UCLA PCI上的性困扰评分为50相当于扩展前列腺癌指数综合评分为56至88。

结论

UCLA PCI的排尿和性功能领域与扩展前列腺癌指数综合评分显示出很强的相关性。相比之下,肠道领域的相关性相对较弱。UCLA PCI与扩展前列腺癌指数综合评分之间的链接分析结果可能对它们的解释有有用的启示。

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