[通过比较基因组杂交分析外阴鳞状细胞癌中的染色体畸变]
[Chromosomal aberration in vulvar squamous cell carcinoma analyzed by comparative genomic hybridization].
作者信息
Ouyang Ling, Zhang Shu-Lan, Chen Rong-Li, Li Bo, Chen Li-Li
机构信息
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, P. R. China.
出版信息
Ai Zheng. 2007 Jun;26(6):572-5.
BACKGROUND & OBJECTIVE: Vulvar squamous cell carcinoma (VSCC) accounts for about 80%-90% of female vulvar malignant tumors, but the etiology is still unclear. This study was to identify genetic alteration in VSCC by comparative genomic hybridization (CGH).
METHODS
The genomic imbalance, that is, gains or losses of chromosomes, in 21 cases of vulvar squamous cell carcinoma was detected by CGH.
RESULTS
The common chromosomal alterations in VSCC included gains of chromosomes 3q, 8q and 12q, and losses of chromosomes 4p and 3p.
CONCLUSIONS
There are multiple chromosomal aberrations in VSCC. The amplification of the tumor suppressor genes and loss of the oncogenes on these regions may be involved in the development and progression of VSCC.
背景与目的
外阴鳞状细胞癌（VSCC）约占女性外阴恶性肿瘤的80%-90%，但其病因仍不清楚。本研究旨在通过比较基因组杂交（CGH）鉴定VSCC中的基因改变。
方法
采用CGH检测21例外阴鳞状细胞癌的基因组失衡情况，即染色体的增加或缺失。
结果
VSCC常见的染色体改变包括3q、8q和12q染色体增加，以及4p和3p染色体缺失。
结论
VSCC存在多种染色体畸变。这些区域的抑癌基因扩增和癌基因缺失可能参与了VSCC的发生和发展。
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