Pryjma J, Ernst M, Fetting R, Woloszyn M, Zembala M, Flad H D
Department of Clinical Immunology and Microbiology, Medical School, Cracow, Poland.
Eur Cytokine Netw. 1991 Aug-Sep;2(4):273-9.
The data presented show that the production of interferon gamma (IFN-gamma) by pokeweed mitogen (PWM)-activated T lymphocytes requires monocytes and that the amount of lymphokine produced depends on the number of monocytes present in the culture. Accessory function of monocytes was independent from their ability to secrete IL-1 but required cell-cell contact, since blocking of adhesion molecules reduced the IFN-gamma production. Furthermore, production of IFN by lectin-preactivated T lymphocytes could not be triggered by IL-2 but also required monocyte-T cell interaction.
所呈现的数据表明，商陆丝裂原（PWM）激活的T淋巴细胞产生γ干扰素（IFN-γ）需要单核细胞，并且产生的淋巴因子量取决于培养物中存在的单核细胞数量。单核细胞的辅助功能与其分泌白细胞介素-1（IL-1）的能力无关，但需要细胞间接触，因为粘附分子的阻断会降低IFN-γ的产生。此外，凝集素预激活的T淋巴细胞产生的IFN不能由IL-2触发，也需要单核细胞与T细胞的相互作用。
