Riekkinen P, Riekkinen M, Lahtinen H, Sirviö J, Valjakka A, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res Bull. 1991 Nov;27(5):587-94. doi: 10.1016/0361-9230(91)90031-e.
The present study examines whether tetrahydroaminoacridine (THA) can improve the deterioration in passive avoidance (PA) retention performance induced by medial septal (MS) and fimbria-fornix (FF) lesions in young rats or by aging. Retention of young MS-lesioned rats was improved by pretraining injection of THA at 3 mg/kg, but not by THA at 1 mg/kg or by either of the posttraining doses of THA (1 and 3 mg/kg). Pretraining injections of THA at 1 or 3 mg/kg had no effect on the PA retention performance of FF-lesioned rats. Age-induced PA failure was alleviated by pretraining administration of THA at 1 and 3 mg/kg. Posttraining injections of THA (1 or 3 mg/kg) had no effect on PA retention performance of aged rats. These results demonstrate that 1) THA may improve hippocampal cholinergic denervation-induced functional deficits and 2) some of the age-related PA deficits may be due to a cholinergic deficit and can be reversed with THA.
本研究考察了四氢氨基吖啶（THA）能否改善幼鼠内侧隔区（MS）和穹窿海马伞（FF）损伤或衰老所致的被动回避（PA）记忆保持能力的衰退。对幼龄MS损伤大鼠，训练前注射3mg/kg的THA可改善其记忆保持能力，但1mg/kg的THA或训练后注射的两种剂量（1mg/kg和3mg/kg）的THA均无此作用。训练前注射1mg/kg或3mg/kg的THA对FF损伤大鼠的PA记忆保持能力无影响。训练前给予1mg/kg和3mg/kg的THA可缓解衰老所致的PA记忆缺失。训练后注射THA（1mg/kg或3mg/kg）对老龄大鼠的PA记忆保持能力无影响。这些结果表明：1）THA可能改善海马胆碱能去神经支配所致的功能缺陷；2）一些与年龄相关的PA记忆缺失可能归因于胆碱能缺陷，且可被THA逆转。
