Féger J, Mouroux M
Laboratoire de Pharmacologie, Faculté des Sciences pharmaceutiques et biologiques, Université René-Descartes, Paris.
C R Acad Sci III. 1991;313(10):447-52.
The synaptic effect of the projection from an intralaminar thalamic structure, the parafascicular nucleus, to the subthalamic nucleus was investigated through extracellular recordings of subthalamic unit activities. Electrical stimulation of the parafascicular nucleus caused a complex response with two successive excitatory phases. The first excitation was assumed to be monosynaptically driven since it was not affected by pallidal lesion or transsection of the internal capsule. Pharmacological activation of the parafascicular neurons through microinjections of carbachol elicited a prolonged increase in the subthalamic discharge rate. These results suggest that the intralaminar parafascicular nucleus contributes to the activation of subthalamic neurons.
通过对丘脑底核单位活动进行细胞外记录，研究了丘脑板内核群结构——束旁核向丘脑底核投射的突触效应。对束旁核进行电刺激会引发一个具有两个连续兴奋期的复杂反应。由于第一个兴奋不受苍白球损伤或内囊横断的影响，因此被认为是单突触驱动的。通过微量注射卡巴胆碱对束旁核神经元进行药理学激活，可使丘脑底核放电率持续增加。这些结果表明，丘脑板内的束旁核参与了丘脑底核神经元的激活。
