慢性背痛患者鉴别诊断中的褐黄病：文献综述

Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature.

作者信息

Capkin Erhan, Karkucak Murat, Yayli Savaş, Serdaroğlu Münevver, Tosun Mehmet

机构信息

Physical Medicine and Rehabilitation Department, Yavuz Selim Bone Diseases and Rehabilitation Hospital, Trabzon, Turkey.

出版信息

Rheumatol Int. 2007 Nov;28(1):61-4. doi: 10.1007/s00296-007-0381-y. Epub 2007 Jun 13.

DOI:10.1007/s00296-007-0381-y

PMID:17564710

Abstract

A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish-brown pigmentation in the nose and ears, dark urine colors following alkalization, and high levels of homogentisic acid in the urine. Ochronosis should be considered in the differential diagnosis of patients with chronic low-back pain regarding features of widespread calcification in the intervertebral discs at radiography and bluish-brown pigmentation in the nose and ears.

摘要

一名50岁男性主诉过去20年来一直存在下背痛和广泛的关节疼痛。传统X线摄影显示椎间盘广泛钙化区域以及外周关节退变改变。通过观察鼻和耳部的蓝褐色色素沉着、碱化后尿液颜色变深以及尿中高含量的尿黑酸，诊断为褐黄病。对于慢性下背痛患者，在鉴别诊断时应考虑褐黄病，其特征包括X线摄影显示椎间盘广泛钙化以及鼻和耳部蓝褐色色素沉着。