Kovacevic Miljenko, Simic Ognjen, Medved Igor, Lucin Ksenija, Padovan Marijan
Department of Cardiac Surgery, University Hospital Rijeka, Croatia.
J Heart Valve Dis. 2006 Sep;15(5):730-2.
A 64-year-old male patient with unknown alkaptonuria and severe aortic stenosis and ischemic heart disease was admitted to the authors' institution for elective surgery. The patient underwent aortic valve replacement with a 25-mm aortic valve (ATS Medical, Inc.) and single venous aortocoronary artery bypass grafting for a right coronary artery. Aortotomy revealed typical ochronotic pigmentation of a severely calcified aortic valve and aortic intima. A diagnosis of alkaptonuria was confirmed by evidence of homogentisic acid in the patient's urine, together with histopathological analysis.
一名64岁男性患者，患有未知的尿黑酸尿症、严重主动脉瓣狭窄和缺血性心脏病，因择期手术入住作者所在机构。患者接受了主动脉瓣置换术，使用了一个25毫米的主动脉瓣（ATS Medical, Inc.），并对右冠状动脉进行了单支静脉主动脉冠状动脉搭桥术。主动脉切开术显示严重钙化的主动脉瓣和主动脉内膜有典型的褐黄病色素沉着。通过患者尿液中尿黑酸的证据以及组织病理学分析，确诊为尿黑酸尿症。
