Gross Andreas J, Herrmann Thomas R W
Abteilung für Urologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.
World J Urol. 2007 Jun;25(3):217-20. doi: 10.1007/s00345-007-0173-8. Epub 2007 Jun 13.
The developments of laser technology from the cradle of modern physics in 1900 by Planck to its latest medical boundaries is an exciting example of how basic physics finds its way into clinical practice. This article merits the protagonists and their contribution to the steps in this development. The competition between the different research groups finally led to the award of the Nobel Prize to Townes, Basov and Prokhorov in 1964 for the scientific basis on quantum electronics, which led to the construction of oscillators and amplifiers based on the laser-maser principle. Forty-three years after Einstein's first theories Maiman introduced the first ruby laser for commercial use. This marked the key step for the laser application and pioneered fruitful cooperations between basic and clinical science. The pioneers of lasers in clinical urology were Parsons in 1966 with studies in canine bladders and Mulvany 1968 with experiments in calculi fragmentation. The central technological component for the triumphal procession of lasers in urology is the endoscope. Therefore lasers are currently widely used, being the tool of choice in some areas, such as endoscopical lithotriptic stone treatment or endoluminal organ-preserving tumor ablation. Furthermore they show promising treatment alternatives for the treatment of benign prostate hyperplasia.
从1900年普朗克开创现代物理学以来激光技术的发展,直至其最新的医学应用领域,是基础物理学如何融入临床实践的一个激动人心的例子。本文值得一提的是那些推动这一发展进程的主角及其贡献。不同研究团队之间的竞争最终促使汤斯、巴索夫和普罗霍罗夫于1964年因量子电子学的科学基础而获得诺贝尔奖,该基础促成了基于激光 - 微波激射原理的振荡器和放大器的构建。在爱因斯坦提出最初理论43年后,梅曼推出了第一台商业用红宝石激光器。这标志着激光应用的关键一步,并开创了基础科学与临床科学之间卓有成效的合作。临床泌尿外科激光技术的先驱是1966年对犬膀胱进行研究的帕森斯,以及1968年进行结石破碎实验的马尔瓦尼。泌尿外科中激光得以广泛应用的核心技术部件是内窥镜。因此,激光目前被广泛使用,在某些领域成为首选工具,比如内镜碎石治疗或腔内器官保留性肿瘤消融。此外,它们在良性前列腺增生的治疗方面也展现出有前景的替代治疗方案。