骨巨细胞瘤中的染色体异常。
Chromosomal abnormalities in giant cell tumors of bone.
作者信息
Bardi G, Pandis N, Mandahl N, Heim S, Sfikas K, Willén H, Panagiotopoulos G, Rydholm A, Mitelman F
机构信息
Department of Cellular Physiology, Papanikolaou Research Center, Athens, Greece.
出版信息
Cancer Genet Cytogenet. 1991 Dec;57(2):161-7. doi: 10.1016/0165-4608(91)90147-m.
Cytogenetic analysis of short-term cultures from ten giant cell tumors of bone revealed clonal and nonclonal chromosome abnormalities in three tumors and nonclonal changes only in seven. None of the clonal aberrations, inv(21)(p11q21) in one tumor, +5 in another, and t(15q22q), dic(4;22)(p16;p1?), double minutes, dicentrics, and ring chromosomes present in three separate clones in the third tumor, were identical to previously reported clonal changes in giant cell tumors. Telomeric associations were found in five tumors. The telomeres of chromosome arms 19q and 15p were particularly frequently involved.
对来自10例骨巨细胞瘤的短期培养物进行细胞遗传学分析，结果显示，3例肿瘤存在克隆性和非克隆性染色体异常，7例仅有非克隆性改变。在1例肿瘤中发现的克隆性畸变inv(21)(p11q21)、另1例中的+5，以及第3例肿瘤中3个独立克隆中出现的t(15q22q)、dic(4;22)(p16;p1?)、双微体、双着丝粒染色体和环状染色体，均与先前报道的骨巨细胞瘤克隆性改变不同。在5例肿瘤中发现了端粒联合。19q和15p染色体臂的端粒尤其经常受累。
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