Kodera Yasuhiro, Nakanishi Hayao, Ito Seiji, Nakao Akimasa
Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Gan To Kagaku Ryoho. 2007 Jun;34(6):817-23.
A certain percentage of patients with cancer suffer from recurrences following surgery with curative intent. This suggests the existence of isolated cancer cells and micrometastases that cannot be detected by routine preoperative imaging studies and intraoperative observations. Recently, such micrometastases have been detected from various clinical samples such as peripheral blood, bone marrow aspirates, lymph nodes, and peritoneal washes, using molecular biology techniques, and it is now possible to more accurately stage patients and individualize adjuvant treatment strategies based on the information obtained through these methods. The prognostic impact of detecting micrometastasis is highly variable and seems to depend on the type of cancer and the specimen from which it was detected. In this review,the authors describe the relevance of micrometastases detected in various body components of patients with gastric cancer, and propose how the information thus obtained could be reflected in the treatment strategy.
一定比例的癌症患者在接受根治性手术后会出现复发情况。这表明存在孤立癌细胞和微转移灶，而这些在术前常规影像学检查和术中观察中无法被检测到。最近，利用分子生物学技术已从外周血、骨髓穿刺液、淋巴结和腹腔灌洗液等各种临床样本中检测到此类微转移灶，现在能够根据通过这些方法获得的信息更准确地对患者进行分期，并制定个体化的辅助治疗策略。检测到微转移灶对预后的影响差异很大，似乎取决于癌症类型以及检测到微转移灶的标本。在这篇综述中，作者描述了在胃癌患者各种身体部位检测到的微转移灶的相关性，并提出如何将由此获得的信息应用于治疗策略中。
