Hogue R, Graves M, Moler S, Janda J M
Microbial Diseases Laboratory, California Department of Health Services, 850 Marina Bay Parkway, Room E164, Richmond, CA 94804, USA.
Infection. 2007 Jun;35(3):126-33. doi: 10.1007/s15010-007-6282-x.
Over the past several decades, the appearance of pink-pigmented bacteria in clinical specimens has gone from being a microbiologic curiosity in the clinical laboratory to the recognition of these aerobic microorganisms as etiologic agents of human disease, most notably bloodstream infections. Advances in the fields of molecular taxonomy and phylogenetics indicate that at least four distinct genera and eight different species are associated with clinical infections in susceptible patient populations. However, these bacteria are slow growing and present multiple diagnostic challenges to the microbiology laboratory including culture, isolation, and identification to species rank. This article provides a current review of these unusual non-fermentative chromogenic bacteria including their disease spectrum, taxonomy, and laboratory identification. The review also highlights the pitfalls or shortcomings we currently have in our knowledge of these microbes and their disease-producing capabilities.
在过去几十年间，临床标本中粉红色色素细菌的出现，已从临床实验室里的一种微生物学奇闻，转变为认识到这些需氧微生物是人类疾病的病原体，最显著的是血流感染。分子分类学和系统发育学领域的进展表明，至少有四个不同的属和八个不同的种与易感患者群体中的临床感染有关。然而，这些细菌生长缓慢，给微生物学实验室带来了多重诊断挑战，包括培养、分离以及鉴定到种的水平。本文对这些不寻常的非发酵产色素细菌进行了综述，包括它们的疾病谱、分类学和实验室鉴定。该综述还强调了我们目前在对这些微生物及其致病能力的认识方面存在的缺陷或不足。
