同种异体胎儿排斥反应在子痫前期中的病因学作用。
The etiological role of allogeneic fetal rejection in pre-eclampsia.
作者信息
Nishizawa Haruki, Hasegawa Kiyoshi, Suzuki Machiko, Kamoshida Shingo, Kato Takema, Saito Kuniaki, Tsutsumi Yutaka, Kurahashi Hiroki, Udagawa Yasuhiro
机构信息
Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
出版信息
Am J Reprod Immunol. 2007 Jul;58(1):11-20. doi: 10.1111/j.1600-0897.2007.00484.x.
PROBLEM
It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia.
METHOD OF STUDY
We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies.
RESULTS
IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity.
CONCLUSION
Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.
问题
已证实正常妊娠中的同种异体胎儿排斥反应可通过胎盘吲哚胺2,3-双加氧酶（IDO）来预防。此外，子痫前期涉及免疫病因。
研究方法
我们检测了正常妊娠和子痫前期妊娠胎盘IDO活性的差异。
结果
重度子痫前期患者胎盘的IDO mRNA表达和酶活性水平较低。酶活性也与患者血压呈负相关。在重度子痫前期的胎盘中，IDO免疫反应性较低，而局部T细胞浸润与IDO活性呈反比。
结论
我们的研究结果表明IDO活性以及母体对同种异体胎儿的免疫反应在子痫前期病因中可能发挥作用。
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