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Maternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).

Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (S.A.W., A.E.P.H., A.G., J.E.M.).

出版信息

Circ Res. 2021 May 28;128(11):1679-1693. doi: 10.1161/CIRCRESAHA.120.317612. Epub 2021 Mar 3.

DOI:10.1161/CIRCRESAHA.120.317612

Abstract

[Figure: see text].

摘要

[图：见正文]。

相似文献

1

Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.犬尿氨酸使正常血压女性和先兆子痫女性的血管松弛。

Circ Res. 2021 May 28;128(11):1679-1693. doi: 10.1161/CIRCRESAHA.120.317612. Epub 2021 Mar 3.

2

Diverse mechanisms of endothelium-derived hyperpolarizing factor-mediated dilatation in small myometrial arteries in normal human pregnancy and preeclampsia.正常妊娠和子痫前期中小子宫肌层动脉中内皮源性超极化因子介导的舒张的不同机制。

Biol Reprod. 2010 Nov;83(5):728-35. doi: 10.1095/biolreprod.110.084426. Epub 2010 Jul 7.

3

Impaired function of coronary BK(Ca) channels in metabolic syndrome.代谢综合征中冠状动脉大电导钙激活钾通道（BK(Ca)）功能受损。

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1629-37. doi: 10.1152/ajpheart.00466.2009. Epub 2009 Sep 11.

4

Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles.小电导钙激活钾通道在缓激肽诱导的猪视网膜小动脉血管舒张中的作用。

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3819-25. doi: 10.1167/iovs.08-3168. Epub 2009 Feb 28.

5

Endothelium-independent relaxation to raloxifene in porcine coronary artery.雷洛昔芬对猪冠状动脉的非内皮依赖性舒张作用。

Eur J Pharmacol. 2007 Jan 26;555(2-3):178-84. doi: 10.1016/j.ejphar.2006.10.035. Epub 2006 Oct 20.

6

Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia.子痫前期患者子宫肌层阻力动脉中内皮依赖性舒张功能丧失。

Br J Obstet Gynaecol. 1997 Oct;104(10):1152-8. doi: 10.1111/j.1471-0528.1997.tb10939.x.

7

l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta.l-色氨酸诱导的血管舒张在子痫前期增强：关于其在人胎盘摄取和代谢的研究

Hypertension. 2020 Jul;76(1):184-194. doi: 10.1161/HYPERTENSIONAHA.120.14970. Epub 2020 Jun 1.

8

Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia.磷酸二酯酶-5抑制剂与正常妊娠和子痫前期的网膜及胎盘小动脉功能

Eur J Obstet Gynecol Reprod Biol. 2006 Jul;127(1):41-9. doi: 10.1016/j.ejogrb.2004.06.014.

9

A comparative study of vascular responsiveness of myometrial and omental small resistance arteries in late-gestation sheep.妊娠晚期绵羊子宫肌层和网膜小阻力动脉血管反应性的比较研究。

Am J Obstet Gynecol. 1999 Sep;181(3):663-8. doi: 10.1016/s0002-9378(99)70510-7.

10

Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A2 mimetic U46619 and 17beta-estradiol.抑制环氧化酶而非一氧化氮合酶会影响血栓素A2模拟物U46619和17β-雌二醇对人网膜动脉的作用。

Am J Obstet Gynecol. 2001 Jul;185(1):182-9. doi: 10.1067/mob.2001.113909.

引用本文的文献

1

Fructose-1,6-bisphosphate reverses hypotensive effect caused by L-kynurenine in Wistar male rats.果糖-1,6-二磷酸逆转 L-犬尿氨酸引起的 Wistar 雄性大鼠的降压作用。

Physiol Rep. 2024 Oct;12(19):e70033. doi: 10.14814/phy2.70033.

2

First trimester maternal tryptophan metabolism and embryonic and fetal growth: the Rotterdam Periconceptional Cohort (Predict Study).早孕期母体色氨酸代谢与胚胎及胎儿生长：鹿特丹围孕期队列（Predict 研究）。

Hum Reprod. 2024 May 2;39(5):912-922. doi: 10.1093/humrep/deae046.

3

Cycling matters: Sex hormone regulation of vascular potassium channels.

本文引用的文献

1

The kynurenine pathway; A new target for treating maternal features of preeclampsia?犬尿酸途径：治疗子痫前期母体特征的新靶点？

Placenta. 2019 Sep 1;84:44-49. doi: 10.1016/j.placenta.2019.04.007. Epub 2019 May 1.

2

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.单线态氧在炎症中调节血管张力和血压。

Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13.

3

Indications for delivery in pre-eclampsia.子痫前期的分娩指征。

犬尿氨酸使正常血压女性和先兆子痫女性的血管松弛。

Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.

机构信息

Maternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).

Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (S.A.W., A.E.P.H., A.G., J.E.M.).

出版信息

Circ Res. 2021 May 28;128(11):1679-1693. doi: 10.1161/CIRCRESAHA.120.317612. Epub 2021 Mar 3.

DOI:10.1161/CIRCRESAHA.120.317612

Abstract

[Figure: see text].

摘要

[图：见正文]。

相似文献

1

Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.犬尿氨酸使正常血压女性和先兆子痫女性的血管松弛。

Circ Res. 2021 May 28;128(11):1679-1693. doi: 10.1161/CIRCRESAHA.120.317612. Epub 2021 Mar 3.

2

Diverse mechanisms of endothelium-derived hyperpolarizing factor-mediated dilatation in small myometrial arteries in normal human pregnancy and preeclampsia.正常妊娠和子痫前期中小子宫肌层动脉中内皮源性超极化因子介导的舒张的不同机制。

Biol Reprod. 2010 Nov;83(5):728-35. doi: 10.1095/biolreprod.110.084426. Epub 2010 Jul 7.

3

Impaired function of coronary BK(Ca) channels in metabolic syndrome.代谢综合征中冠状动脉大电导钙激活钾通道（BK(Ca)）功能受损。

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1629-37. doi: 10.1152/ajpheart.00466.2009. Epub 2009 Sep 11.

4

Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles.小电导钙激活钾通道在缓激肽诱导的猪视网膜小动脉血管舒张中的作用。

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3819-25. doi: 10.1167/iovs.08-3168. Epub 2009 Feb 28.

5

Endothelium-independent relaxation to raloxifene in porcine coronary artery.雷洛昔芬对猪冠状动脉的非内皮依赖性舒张作用。

Eur J Pharmacol. 2007 Jan 26;555(2-3):178-84. doi: 10.1016/j.ejphar.2006.10.035. Epub 2006 Oct 20.

6

Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia.子痫前期患者子宫肌层阻力动脉中内皮依赖性舒张功能丧失。

Br J Obstet Gynaecol. 1997 Oct;104(10):1152-8. doi: 10.1111/j.1471-0528.1997.tb10939.x.

7

l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta.l-色氨酸诱导的血管舒张在子痫前期增强：关于其在人胎盘摄取和代谢的研究

Hypertension. 2020 Jul;76(1):184-194. doi: 10.1161/HYPERTENSIONAHA.120.14970. Epub 2020 Jun 1.

8

Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia.磷酸二酯酶-5抑制剂与正常妊娠和子痫前期的网膜及胎盘小动脉功能

Eur J Obstet Gynecol Reprod Biol. 2006 Jul;127(1):41-9. doi: 10.1016/j.ejogrb.2004.06.014.

9

A comparative study of vascular responsiveness of myometrial and omental small resistance arteries in late-gestation sheep.妊娠晚期绵羊子宫肌层和网膜小阻力动脉血管反应性的比较研究。

Am J Obstet Gynecol. 1999 Sep;181(3):663-8. doi: 10.1016/s0002-9378(99)70510-7.

10

Inhibition of cyclooxygenase but not nitric oxide synthase influences effects on the human omental artery of the thromboxane A2 mimetic U46619 and 17beta-estradiol.抑制环氧化酶而非一氧化氮合酶会影响血栓素A2模拟物U46619和17β-雌二醇对人网膜动脉的作用。

Am J Obstet Gynecol. 2001 Jul;185(1):182-9. doi: 10.1067/mob.2001.113909.

引用本文的文献

1

Fructose-1,6-bisphosphate reverses hypotensive effect caused by L-kynurenine in Wistar male rats.果糖-1,6-二磷酸逆转 L-犬尿氨酸引起的 Wistar 雄性大鼠的降压作用。

Physiol Rep. 2024 Oct;12(19):e70033. doi: 10.14814/phy2.70033.

2

First trimester maternal tryptophan metabolism and embryonic and fetal growth: the Rotterdam Periconceptional Cohort (Predict Study).早孕期母体色氨酸代谢与胚胎及胎儿生长：鹿特丹围孕期队列（Predict 研究）。

Hum Reprod. 2024 May 2;39(5):912-922. doi: 10.1093/humrep/deae046.

3

Cycling matters: Sex hormone regulation of vascular potassium channels.

本文引用的文献

1

The kynurenine pathway; A new target for treating maternal features of preeclampsia?犬尿酸途径：治疗子痫前期母体特征的新靶点？

Placenta. 2019 Sep 1;84:44-49. doi: 10.1016/j.placenta.2019.04.007. Epub 2019 May 1.

2

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.单线态氧在炎症中调节血管张力和血压。

Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13.

3

Indications for delivery in pre-eclampsia.子痫前期的分娩指征。

骑行很重要：血管钾通道的性激素调节。

Channels (Austin). 2023 Dec;17(1):2217637. doi: 10.1080/19336950.2023.2217637.

4

Novel mechanism of increased preeclampsia risk after kidney donation.肾移植后子痫前期风险增加的新机制。

Kidney Int. 2023 Apr;103(4):653-655. doi: 10.1016/j.kint.2023.01.013.

5

The curious case of tryptophan in pregnancy.孕期色氨酸的奇特案例。

J Clin Invest. 2022 Oct 17;132(20):e164219. doi: 10.1172/JCI164219.

6

Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway.肾储备功能障碍通过犬尿氨酸和可溶性 fms 样酪氨酸激酶 1 途径导致子痫前期。

J Clin Invest. 2022 Oct 17;132(20):e158346. doi: 10.1172/JCI158346.

7

The Footprint of Kynurenine Pathway in Cardiovascular Diseases.犬尿氨酸途径在心血管疾病中的印记

Int J Tryptophan Res. 2022 Jun 28;15:11786469221096643. doi: 10.1177/11786469221096643. eCollection 2022.

8

Unbalanced IDO1/IDO2 Endothelial Expression and Skewed Keynurenine Pathway in the Pathogenesis of COVID-19 and Post-COVID-19 Pneumonia.IDO1/IDO2内皮细胞表达失衡及犬尿氨酸途径异常在COVID-19及新冠后肺炎发病机制中的作用

Biomedicines. 2022 Jun 6;10(6):1332. doi: 10.3390/biomedicines10061332.

9

Tryptophan regulates zinc stores.色氨酸调节锌的储存。

Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2117807119. doi: 10.1073/pnas.2117807119. Epub 2022 Apr 11.

10

The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?色氨酸代谢通路在胎盘的功能：一个新的药物治疗靶点？

Int J Environ Res Public Health. 2021 Nov 3;18(21):11545. doi: 10.3390/ijerph182111545.

Pregnancy Hypertens. 2018 Jan;11:12-17. doi: 10.1016/j.preghy.2017.11.004. Epub 2017 Dec 8.

4

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).色氨酸衍生物能够强烈激活芳香烃受体（AHR）。

J Biol Chem. 2018 Feb 9;293(6):1994-2005. doi: 10.1074/jbc.RA117.000631. Epub 2017 Dec 26.

5

Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.小鼠中犬尿氨酸途径代谢的产前动态：聚焦于犬尿喹啉酸

Dev Neurosci. 2017;39(6):519-528. doi: 10.1159/000481168. Epub 2017 Oct 28.

6

The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.SIRT1、SIRT3 和 SIRT6 这三种长寿蛋白家族成员：它们在血管生物学和动脉粥样硬化形成中的作用。

Atherosclerosis. 2017 Oct;265:275-282. doi: 10.1016/j.atherosclerosis.2017.08.027. Epub 2017 Aug 26.

7

Importance of kynurenine in pulmonary hypertension.犬尿氨酸在肺动脉高压中的重要性。

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L741-L751. doi: 10.1152/ajplung.00517.2016. Epub 2017 Jul 13.

8

Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.心血管疾病中色氨酸分解代谢的异常犬尿氨酸途径。

Cell Mol Life Sci. 2017 Aug;74(16):2899-2916. doi: 10.1007/s00018-017-2504-2. Epub 2017 Mar 17.

9

Kynurenic Acid in Schizophrenia: A Systematic Review and Meta-analysis.精神分裂症中犬尿氨酸酸：系统评价和荟萃分析。

Schizophr Bull. 2017 Jul 1;43(4):764-777. doi: 10.1093/schbul/sbw221.

10

Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.调节色氨酸代谢中犬尿氨酸和血清素途径之间的平衡。

FEBS J. 2017 Mar;284(6):948-966. doi: 10.1111/febs.14026. Epub 2017 Feb 20.

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Suppr 超能文献

文献检索

文件翻译

深度研究

犬尿氨酸使正常血压女性和先兆子痫女性的血管松弛。

Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

犬尿氨酸使正常血压女性和先兆子痫女性的血管松弛。

Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献