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Paradoxical roles of the immune system during cancer development.免疫系统在癌症发展过程中的矛盾作用。
Nat Rev Cancer. 2006 Jan;6(1):24-37. doi: 10.1038/nrc1782.
2
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.人卵巢癌细胞分泌的白细胞介素-6是一种强效促血管生成细胞因子。
Cancer Res. 2005 Dec 1;65(23):10794-800. doi: 10.1158/0008-5472.CAN-05-0623.
3
CD40/CD154 interactions at the interface of tolerance and immunity.耐受性与免疫交界处的CD40/CD154相互作用。
Annu Rev Immunol. 2004;22:307-28. doi: 10.1146/annurev.immunol.22.012703.104533.
4
Constitutive expression of TGF-bêta1, interleukin-6 and interleukin-8 by tumor cells as a major component of immune escape in human ovarian carcinoma.
Eur Cytokine Netw. 2003 Oct-Dec;14(4):246-55.
5
EpCAM: A new therapeutic target for an old cancer antigen.上皮细胞黏附分子（EpCAM）：一种古老癌症抗原的新治疗靶点。
Cancer Biol Ther. 2003 Jul-Aug;2(4):320-6. doi: 10.4161/cbt.2.4.451.
6
Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cells.人黑色素瘤细胞表达的抑制性Fc（γ）受体对肿瘤生长的调节作用
J Clin Invest. 2002 Nov;110(10):1549-57. doi: 10.1172/JCI15454.
7
Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.核因子κB激活剂Act1在上皮细胞中CD40介导的信号传导中的作用。
Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9386-91. doi: 10.1073/pnas.142294499. Epub 2002 Jun 27.
8
Roles of the ovarian surface epithelium in ovulation and carcinogenesis.卵巢表面上皮在排卵和致癌作用中的角色。
Reproduction. 2002 Jun;123(6):743-50. doi: 10.1530/rep.0.1230743.
9
CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion.上皮性卵巢癌细胞中的CD40激活可调节细胞生长、凋亡和细胞因子分泌。
Mol Pathol. 2002 Apr;55(2):110-20. doi: 10.1136/mp.55.2.110.
10
Expression of metastasis-related genes in human epithelial ovarian tumors.人上皮性卵巢肿瘤中转移相关基因的表达
Int J Oncol. 2002 Jan;20(1):5-13.

CD40结合对体外卵巢癌细胞生长和细胞因子产生的影响。

Effects of CD40 binding on ovarian carcinoma cell growth and cytokine production in vitro.

作者信息

Toutirais O, Gervais A, Cabillic F, Le Gallo M, Coudrais A, Levêque J, Catros-Quemener V, Genetet N

机构信息

UPRES 3891, Faculté de Médecine de Rennes, Rennes, France.

出版信息

Clin Exp Immunol. 2007 Aug;149(2):372-7. doi: 10.1111/j.1365-2249.2007.03426.x. Epub 2007 Jun 12.

DOI:10.1111/j.1365-2249.2007.03426.x
PMID:17565609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1941941/
Abstract

The poor prognosis associated with ovarian carcinoma (OVCA) is linked to the high incidence of local recurrence. There is a pressing need to identify factors that can play a role in OVCA growth and spread. Here, we focused on CD40, a member of the tumour necrosis factor (TNF) receptor superfamily with important functions in immune response. The expression of CD40 has been reported on various types of carcinoma cells, but its biological role is still poorly understood. The aim of the present study was to investigate the expression and function of the CD40 in OVCA cell lines. Detectable CD40 levels ranging from low to very high were found on the cell surface of several OVCA cell lines by flow cytometry analysis. Co-culture with a murine cell line transfected with CD40 ligand (CD40L) inhibited cell growth and up-regulated the secretion of proinflammatory cytokines interleukin (IL)-6, IL-8 and TNF-alpha in high-level CD40-expressing OVCA cell lines. Similarly, an increase of IL-6 and IL-8 release could be obtained by adding a soluble form of CD40L to the OVCA cultures. These results suggest that CD40-CD40L interaction is an important pathway affecting growth regulation and cytokine production in OVCA.

摘要

与卵巢癌（OVCA）相关的不良预后与局部复发的高发生率有关。迫切需要确定在OVCA生长和扩散中起作用的因素。在此，我们聚焦于CD40，它是肿瘤坏死因子（TNF）受体超家族的成员，在免疫反应中具有重要功能。已有报道称CD40在各种类型的癌细胞上表达，但其生物学作用仍知之甚少。本研究的目的是调查CD40在OVCA细胞系中的表达和功能。通过流式细胞术分析发现，几种OVCA细胞系的细胞表面存在可检测到的CD40水平，范围从低到非常高。与转染了CD40配体（CD40L）的小鼠细胞系共培养可抑制高表达CD40的OVCA细胞系的细胞生长，并上调促炎细胞因子白细胞介素（IL）-6、IL-8和肿瘤坏死因子-α的分泌。同样，通过向OVCA培养物中添加可溶性形式的CD40L，可使IL-6和IL-8的释放增加。这些结果表明，CD40-CD40L相互作用是影响OVCA生长调节和细胞因子产生的重要途径。