Bazil Carl W, Battista Julianne, Basner Robert C
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
J Clin Sleep Med. 2005 Jul 15;1(3):284-7.
To evaluate the ability of a single dose of gabapentin to improve sleep disruption caused by alcohol consumption.
Double-blind, randomized, single-dose, crossover study of normal subjects (age 21-45 years) who were free of known sleep disorders or medical conditions that could interfere with sleep. Subjects first received baseline polysomnography and, upon awakening, subjective scales of drowsiness and functioning. One to 2 weeks later, they returned to the sleep lab. They consumed 4 ounces of 40% alcohol and gabapentin (300 or 600 mg) or placebo 1 hour prior to bedtime. Polysomnography and subjective scales were repeated. One to 2 weeks later, subjects returned and were given the same dose of alcohol and the other treatment, followed by repeat testing. Differences between baseline and placebo (alcohol) results were compared to the difference between baseline and gabapentin (alcohol) by paired t tests.
Thirteen subjects were enrolled; 12 completed the study. Mean age was 30.8 years (range 25-37 years). No difference in total sleep time was seen for any of the groups. Gabapentin (300 or 600 mg) showed a significant decrease in stage 1 (9.3% vs 5.5%) and number of awakenings (11 vs 6) with increased sleep efficiency (93% vs 96.2%). Subjects receiving 600 mg also showed increased slow wave sleep, decreased rapid eye movement sleep, and decreased arousals. No differences were seen in any of the subjective tests of drowsiness and performance.
Single-dose gabapentin at bedtime can improve sleep through decreased stage 1 sleep, increased slow-wave sleep, increased sleep efficiency, and decreased arousals. Gabapentin may be useful in the treatment of conditions in which frequent awakenings and decreased sleep efficiency are seen.
评估单剂量加巴喷丁改善因饮酒导致的睡眠中断的能力。
对无已知睡眠障碍或可能干扰睡眠的医疗状况的正常受试者（年龄21 - 45岁）进行双盲、随机、单剂量、交叉研究。受试者首先接受基线多导睡眠图检查，并在醒来后接受嗜睡和功能的主观量表评估。1至2周后，他们返回睡眠实验室。他们在睡前1小时饮用4盎司40%的酒精，并服用加巴喷丁（300或600毫克）或安慰剂。重复进行多导睡眠图检查和主观量表评估。1至2周后，受试者再次返回并给予相同剂量的酒精和另一种治疗，随后再次进行测试。通过配对t检验比较基线与安慰剂（酒精）结果之间的差异以及基线与加巴喷丁（酒精）结果之间的差异。
招募了13名受试者；12名完成了研究。平均年龄为30.8岁（范围25 - 37岁）。任何一组的总睡眠时间均无差异。加巴喷丁（300或600毫克）组的1期睡眠显著减少（9.3%对5.5%），觉醒次数减少（11次对6次），睡眠效率提高（93%对96.2%）。接受600毫克加巴喷丁的受试者还表现出慢波睡眠增加、快速眼动睡眠减少和觉醒减少。在任何嗜睡和表现的主观测试中均未发现差异。
睡前单剂量加巴喷丁可通过减少1期睡眠、增加慢波睡眠、提高睡眠效率和减少觉醒来改善睡眠。加巴喷丁可能对治疗出现频繁觉醒和睡眠效率降低的情况有用。
