Mislow John M K, Proctor Mark R, McNeely P Daniel, Greene Arin K, Rogers Gary F
Department of Neurosurgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Neurosurg. 2007 Jun;106(6 Suppl):484-9. doi: 10.3171/ped.2007.106.6.484.
Calvarial osteolysis is a relatively rare finding in patients with neurofibromatosis. The authors describe two patients with neurofibromatosis Type 1 (NF1) and extensive cranial defects associated with underlying dural ectasia. Cranioplasties were performed in both patients with mixed results. One patient underwent cranioplasty using titanium mesh and methylmethacrylate. The other patient underwent an extensive cranioplasty with autogenous iliac crest grafting, and after initial healing has since had further bone resorption. In conclusion, the results of cranial reconstruction in patients with NF1 and dural ectasia are unpredictable because of the tendency for further bone resorption; techniques that protect the graft material from cerebrospinal fluid pulsations via a rigid mesh should be considered.
颅骨骨溶解在神经纤维瘤病患者中是一种相对罕见的表现。作者描述了两名患有1型神经纤维瘤病（NF1）且伴有广泛颅骨缺损及潜在硬脑膜扩张的患者。两名患者均接受了颅骨成形术，结果不一。一名患者使用钛网和甲基丙烯酸甲酯进行颅骨成形术。另一名患者接受了自体髂嵴移植的广泛颅骨成形术，在最初愈合后仍有进一步的骨质吸收。总之，由于存在进一步骨质吸收的倾向，NF1和硬脑膜扩张患者的颅骨重建结果不可预测；应考虑采用通过刚性网片保护移植材料免受脑脊液搏动影响的技术。
