Fernandez Fabian, Garner Craig C
Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, 1201 Welch Rd., Palo Alto, CA 94304-5485, USA.
Neurosci Lett. 2007 Jun 27;421(2):137-41. doi: 10.1016/j.neulet.2007.04.075. Epub 2007 May 29.
Ts1Cje and Ts65Dn are genetic mouse models of Down syndrome (DS). Like individuals with DS, these mice exhibit various hallmarks of hippocampal pathology, and deficits in hippocampal-based, declarative learning and memory tasks. Both spatial navigation and novel object recognition, two prototypical domains of declarative memory function, have been strongly characterized in the Ts65Dn DS model. Indeed, Ts65Dn mice show navigation problems in the Morris water maze, impaired alternation in a T-maze, and deficient working and reference memory in the radial arm maze task. They, likewise, show an inability to detect object novelty over time. In contrast to the Ts65Dn model, hippocampal-dependent cognition has been less well characterized in Ts1Cje. Although Ts1Cje mice have been found to exhibit spatial difficulties in the Morris water maze and reduced spontaneous alternation, their ability to process object-based information has never been examined. Here, we report that Ts1Cje mice perform normally in short-term and long-term novel object recognition tasks. The ability of Ts1Cje mice to detect object novelty, unlike Ts65Dn, may point to differences in the extent of hippocampal pathology in the two DS mouse models.
Ts1Cje和Ts65Dn是唐氏综合征（DS）的基因小鼠模型。与患有DS的个体一样，这些小鼠表现出各种海马病理特征，以及基于海马的陈述性学习和记忆任务缺陷。陈述性记忆功能的两个典型领域——空间导航和新物体识别，在Ts65Dn DS模型中都有很强的特征描述。事实上，Ts65Dn小鼠在莫里斯水迷宫中表现出导航问题，在T迷宫中交替能力受损，在放射状臂迷宫任务中工作记忆和参考记忆不足。同样，它们也表现出随着时间推移无法检测物体新奇性的情况。与Ts65Dn模型不同，Ts1Cje中依赖海马的认知特征描述较少。尽管已发现Ts1Cje小鼠在莫里斯水迷宫中表现出空间困难和自发交替减少，但其处理基于物体信息的能力从未被研究过。在此，我们报告Ts1Cje小鼠在短期和长期新物体识别任务中表现正常。与Ts65Dn不同，Ts1Cje小鼠检测物体新奇性的能力可能表明这两种DS小鼠模型中海马病理程度的差异。
