Dang Zhao, Yang Yushe, Ji Ruyun, Zhang Shuhua
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4523-6. doi: 10.1016/j.bmcl.2007.05.093. Epub 2007 Jun 6.
The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.
描述了在C-7位具有取代哌啶环的新型氟喹诺酮抗菌剂的设计与合成。大多数新化合物表现出高体外抗菌活性。其中几种对革兰氏阳性菌具有显著活性，比吉米沙星、利奈唑胺和万古霉素的活性更强。
