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Synthesis of 1H-imidazo[1,2-b]-1,2,4-triazol-6-amines via multicomponent reaction.

作者信息

Huang Yan, Hu Xiu-Qin, Shen Da-Peng, Chen Yong-Fei, Xu Peng-Fei

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China.

出版信息

Mol Divers. 2007 May;11(2):73-80. doi: 10.1007/s11030-007-9059-3. Epub 2007 Jun 14.

DOI:10.1007/s11030-007-9059-3
PMID:17566867
Abstract

A simple and effective method for the synthesis of bioactive imidazo[1,2,4]triazole analogues has been developed utilizing the MCR technique, which involved the reaction of aminotriazoles, isocyanides and aldehydes. The products were characterized by (1)H, (13)C NMR spectroscopy, MS and elemental analysis. Interestingly, compounds 19d, 21a, 21b and 21h displayed good cytotoxic activities at 10(-4) M concentration in the inhibition of tumor cell growth as evaluated by the MTT method.

摘要

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Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives.多取代6-氮杂吲哚啉及其三环衍生物的三组分合成
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