Lockington P F, Fa'aea P
Department of Anaesthesiology and Peri-operative Medicine, North Shore Hospital, Auckland, New Zealand.
Anaesthesia. 2007 Jul;62(7):672-6. doi: 10.1111/j.1365-2044.2007.05098.x.
The aim of this study was to assess the antipruritic efficacy of subcutaneous naloxone following intrathecal morphine administration. Fifty women undergoing elective Caesarean section using spinal anaesthesia were randomly allocated, in a double-blind study design, to receive either naloxone 400 microg or placebo as a subcutaneous injection at the end of surgery. Spinal anaesthesia was performed using 0.5% hyperbaric bupivacaine, 25 microg fentanyl and 150 microg of preservative-free morphine sulphate. The primary outcome measures were: incidence of pruritus, nausea and vomiting, and quality of analgesia. The incidence of pruritus and nausea and vomiting was not significantly different between the two groups. There was also no significant difference in postoperative analgesia between the two groups. We conclude that pruritus, following intrathecal fentanyl 25 microg and preservative-free morphine sulphate 150 microg, is not reduced by the addition of naloxone 400 microg administered subcutaneously on the completion of surgery.
本研究的目的是评估鞘内注射吗啡后皮下注射纳洛酮的止痒效果。五十名接受脊髓麻醉下择期剖宫产的女性，在一项双盲研究设计中被随机分配，在手术结束时接受400微克纳洛酮或安慰剂皮下注射。脊髓麻醉采用0.5%的高压布比卡因、25微克芬太尼和150微克无防腐剂硫酸吗啡进行。主要观察指标为：瘙痒、恶心和呕吐的发生率以及镇痛质量。两组之间瘙痒、恶心和呕吐的发生率无显著差异。两组之间术后镇痛也无显著差异。我们得出结论，在鞘内注射25微克芬太尼和150微克无防腐剂硫酸吗啡后，手术结束时皮下注射400微克纳洛酮并不能减轻瘙痒。
